Lipogems®
Autologous Micro-fragmented Adipose Tissue
The Lipogems® system is a sterile, single-use, class IIa medical device for the closed preparation and transfer of autologous adipose tissue in a single surgical step. The harvested tissue is minimally manipulated and used to repair, regenerate or replace damaged tissue structures.
In orthobiology, Lipogems® has proven particularly effective in the treatment of progressive and degenerative osteochondral diseases - such as osteoarthritis or traumatic joint injuries. It supports functional recovery in both younger and older patients with knee or hip joint pain as a result of overuse or trauma. It also enables athletes to return to competitive sport, especially if used early in the course of the disease.
Lipogems® is also used in the AMIC®+ procedure - a single-stage cartilage repair technique supplemented by biological augmentation. The combination of Lipogems® with the proven AMIC® procedure is known as the LIPO-AMIC® technique and has been described in detail by Debieux et al. (2024)1.
A recent five-year follow-up study on the LIPO-AMIC® technique², in which the Chondro-Gide® membrane was combined with autologous mesenchymal stem cells from adipose tissue, showed convincing clinical results in 18 patients with severe cartilage defects in the knee joint (ICRS grade III-IV). Clinical scores improved significantly (IKDC from 36.1 to 87.2; Lysholm from 44.4 to 93.5 points), and MRI findings demonstrated progressive cartilage regeneration and subchondral bone repair. These results indicate that LIPO-AMIC® is an effective and sustainable treatment option - with potentially better regeneration results compared to the standard AMIC® technique.
Key advantages of the Lipogems® system:
- No oxidation or mechanical damage to the cell population during processing
- High flowability and viscosity allow application through very fine needles
- Supplied as a complete disposable kit
- No centrifugation required
- No added enzymes
References:
- Debieux, P. et al. LIPO-AMIC Technique Description: Autologous Matrix Induced–Chondrogenesis With Microfragmented Adipose Tissue Graft. Arthrosc. Tech. 103279 (2024) doi:10.1016/j.eats.2024.103279.
- Sciarretta F.V. et al. One-stage cartilage repair using the autologous matrix-induced chondrogenesis combined with simultaneous use of autologous adipose tissue graft and adipose tissue mesenchymal cells technique: clinical results and magnetic resonance imaging evaluation at five-year follow-up. Int Orthop. 2024 Jan;48(1):267-277. doi: 10.1007/s00264-023-05921-8. Epub 2023 Sep 1. PMID: 37656198; PMCID: PMC10766726.
Lipogems® is distributed by Geistlich in Germany and Brazil.
Legal Manufacturer:
Lipogems
Viale Bianca Maria 24
20129 Milano
Italy
Website: Lipogems.com