For over 40 years, Geistlich Bio‑Oss® has helped clinicians maintain bone volume and implant stability with confidence.4-6,8,11,12 Its slow resorption supports predictable, long-term results where it matters most.4-6,8,11,12
References:
- iData Research, China market report suite for dental bone graft substitutes and other biomaterials, iDATA_CHDBGS18_MS, Nov 2018. (market research)
- iData Research, Europe market report suite for dental bone graft substitutes and other biomaterials, iDATA_EUDBGS19_MS, Jul 2019. (market research)
- iData Research, US market report suite for dental bone graft substitutes and other biomaterials, iDATA_USDBGS19_MS, Jan 2019. (market research)
- Aghaloo TL, Moy PK: Int J Oral Maxillofac Implants 2007; 22 (Suppl): 49–70. (systematic review)
- Jung RE, et al.: Clin Oral Implants Res 2013; 24(10): 1065–73. (clinical study)
- Orsini G, et al.: J Biomed Mater Res B Appl Biomater 2005; 74(1): 448–57. (clinical study)
- Traini T, et al.: J Periodontol 2007; 78(5): 955–61. (clinical study)
- Mordenfeld A, et al.: Clin Oral Implants Res 2010; 21(9): 961–70. (clinical study)
- Maiorana C, et al.: Open Dent J 2011; 5: 71–78. (clinical study)
- Galindo-Moreno P, et al.: Clin Implant Dent Relat Res 2013; 15(6): 858–66. (clinical study)
- Chappuis V, et al.: J Dent Res 2018; 97(3): 266–74. (clinical study)
- Knoefler W, et al.: Int J Implant Dent 2016; 2(1): 25. (clinical study)
- Data on file. Geistlich Pharma AG, Wolhusen, Switzerland.
- Jiang D, et al.: J Periodontol 1999; 70(8): 834–9. (preclinical study)
- Beretta M, et al.: Int J Periodontics Restorative Dent 2025; 45(2): 209–19. (clinical study)
- GEM 21S® Instructions for Use
- Degidi M, et al.: Oral Dis 2006; 12(5): 469–75. (clinical study)
- Weibrich G, et al.: Mund Kiefer Gesichtschir 2000; 4(3): 148–52. (preclinical study)
- Jung RE, et al.: Clin Oral Implants Res 2021; 32(12): 1455–65. (clinical study)
- PubMed search 08 August 2025; search term “bio-oss” (1,402 publications), https://pubmed.ncbi.nlm.nih.gov/?term=bio-oss
- Urban IA, et al.: Int J Periodontics Restorative Dent 2013; 33(3): 299–307. (clinical study)
- Cosyn J, et al.: J Clin Periodontol 2012; 39(10): 979–86. (clinical study)
- Camelo M, et al.: Int J Periodontics Restorative Dent 1998; 18(4): 321–31. (clinical study)
- Lundgren D, Slotte C: J Clin Periodontol 1999; 26(1): 56–62. (clinical study)
- Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2014; 34(5): 631–7. (clinical study)
Geistlich Bio-Oss®
The original natural bone substitute
Fast Liquid Uptake
Geistlich Bio-Oss® granules can be hydrated with saline or blood.
Fast Liquid Uptake
The micro - and macropores of Geistlich Bio-Oss® enable a faster absorption of liquids, nutrients, and growth factors compared to other bone substitutes. Thanks to its high hydrophilicity, the granules become fully hydrated within seconds.
Boosting Performance
Combine the granules with autologous bone and/or biologics to promote a faster healing process.
The Dream Team
Multiple studies confirm that Geistlich Bio-Oss® and Geistlich Bio-Gide® deliver excellent long-term esthetic outcomes and peri-implant health – even 20+ years after the procedure.
Porous with a Purpose
One gram of Geistlich has a surface area of 80 square meters. This vast surface instantly fills with and retains blood, acting as a reservoir for growth factors.
Unmatched Volume Stability
The outstanding osteoconductive properties and slow resorption rate of Geistlich Bio-Oss® promote effective bone regeneration and long-term volume stability.
Excellent Long-Term Implant Survival
Implant survival rates exceed 97% when using Geistlich Bio-Oss®, outperforming sites treated without graft material, with other bone substitutes, or with autologous bone.
Excellent Long-Term Implant Survival
>97% implant survival rate
Excellent Long-Term Implant Survival
Even after 20+ years
Your Advantages at a Glance
- Fast liquid uptake
- High osteoconductivity
- Unmatched volume stability
- Excellent implant survival rate
- Long-lasting esthetic results
Geistlich Bio-Oss®
User Benefits
Geistlich Bio-Oss® is the leading natural bone substitute in regenerative dentistry worldwide1,2. The outstanding osteo-conductive properties of Geistlich Bio-Oss® lead to effective and predictable bone regeneration3-5. Geistlich Bio-Oss® particles become an integral part of the newly formed bone framework and preserve volume over the long-term6-9. Subsequent application of a Geistlich Bio-Gide® collagen membrane enables undisturbed regeneration in the augmented area10.
References:
- Millennium Research Group, Dental Biomaterials North America, 2018 (Market research).
- Millennium Research Group, Dental Biomaterials Europe, 2018 (Market research).
- Orsini G et al.,Oral Dis. 2007, Nov;13(6):586–93 (Clinical study).
- Jung R et al., Clin Oral Implants Res. 2013 Oct;24(10):1065–73 (Clinical study).
- Aghaloo TL et al., Int J Oral Maxillofac Implants. 2007; 22(suppl):49–70 (Clinical study).
- Maiorana C et al., Int J Periodontics Restorative Dent. 2005 Feb;25(1):19–25.(Clinical study)
- Traini T et al., J Periodontol. 2007 May; 78(5):955–61 (Clinical study).
- Mordenfeld A et al., Clin. Oral Implant Res. 2010, Sep;21(9):961–70 (Clinical study).
- Galindo-Moreno P et al., Clin Implant Dent Relat Res. 2013 Dec;15(6):858-66 (Clinical Study).
- Perelman-Karmon M et al., Int J Periodontics Restorative Dent.2012 Aug;32(4):459–65 (Clinical study).
Leading clinicians rely on Geistlich Bio-Oss® because:
- Geistlich Bio-Oss® augmented bone leads to high implant survival rates, comparable with implants placed in pristine bone4,5
- Geistlich Bio-Oss® is easy to apply and can be used in the most varied indications
- Geistlich Bio-Oss® is validated by over 30 years of successful use and testing, documented in more than 1000 scientific publications
In the 1980s, Dr. Peter Geistlich was the first to remove organic components from bone material without changing the natural microstructure and bone composition. Nowadays, Geistlich Bio-Oss® is regarded as the state-of-the-art bone substitute in dental bone regeneration – meeting the requirement from clinicians for predictable outcomes.
Application
Geistlich Bio-Oss® delivers excellent handling and provides reproducible quality in daily clinical use.
- Before application, Geistlich Bio-Oss® is mixed with autogenous blood or a saline solution. Its hydrophilic properties promote rapid and complete hydration
- Geistlich Bio-Oss® is easily modelled and adheres optimally to the walls of the defect site
- Excessive compression should be avoided in order to leave room for new bone ingrowth
- Subsequent application of a collagen membrane such as Geistlich Bio-Gide® enables unimpeded bone regeneration
Product Range
Geistlich Bio-Oss® is available in five convenient quantities of small or large granules, which adapt easily to defect sites.
Small Geistlich Bio-Oss® granules (0.25 – 1 mm)
- Allows good adaptation to surrounding surface contours
- Particularly useful for smaller defects and autogenous block graft contouring
- Available in the following sizes:
- 0.25 g ~ 0.5 cc
- 0.5 g ~ 1 cc
- 1 g ~ 2 cc
- 2 g ~ 4 cc
Large Geistlich Bio-Oss® granules (1 – 2 mm)
- Recommended for larger bone augmentations.
- Available in the following sizes:
- 0.5 g ~ 1.5 cc
- 1 g ~ 3 cc
- 2 g ~ 6 cc
*Product availability may vary from country to country
Not all products presented on this website are registered and approved for sale and usage in all countries or regions by the relevant authorities. Indications of use may also vary by country and region. Please contact your country representative of Geistlich Pharma AG for product availability and information.
