Geistlich Bio-Oss®
Higher implant survival and volume stability start with Geistlich Bio-Oss® – the original natural bone graft substitute for dental implants and bone regeneration. Its bovine-derived granules provide outstanding osteoconductivity, supporting predictable and effective bone regeneration for long-term clinical success. Recognized by clinicians worldwide, it is a reliable dental bone grafting material for a broad range of indications.1-11
References:
- iData Research, China market report suite for dental bone graft substitutes and other biomaterials, iDATA_CHDBGS18_MS, Nov 2018. (market research)
- iData Research, Europe market report suite for dental bone graft substitutes and other biomaterials, iDATA_EUDBGS19_MS, Jul 2019. (market research)
- iData Research, US market report suite for dental bone graft substitutes and other biomaterials, iDATA_USDBGS19_MS, Jan 2019. (market research)
- Aghaloo TL, Moy PK: Int J Oral Maxillofac Implants 2007; 22 (Suppl): 49–70. (systematic review)
- Jung RE, et al.: Clin Oral Implants Res 2013; 24(10): 1065–73. (clinical study)
- Orsini G, et al.: J Biomed Mater Res B Appl Biomater 2005; 74(1): 448–57. (clinical study)
- Traini T, et al.: J Periodontol 2007; 78(5): 955–61. (clinical study)
- Mordenfeld A, et al.: Clin Oral Implants Res 2010; 21(9): 961–70. (clinical study)
- Maiorana C, et al.: Open Dent J 2011; 5: 71–78. (clinical study)
- Galindo-Moreno P, et al.: Clin Implant Dent Relat Res 2013; 15(6): 858–66. (clinical study)
- Chappuis V, et al.: J Dent Res 2018; 97(3): 266–74. (clinical study)
- Knoefler W, et al.: Int J Implant Dent 2016; 2(1): 25. (clinical study)
- Data on file. Geistlich Pharma AG, Wolhusen, Switzerland.
- Jiang D, et al.: J Periodontol 1999; 70(8): 834–9. (preclinical study)
- Beretta M, et al.: Int J Periodontics Restorative Dent 2025; 45(2): 209–19. (clinical study)
- GEM 21S® Instructions for Use
- Degidi M, et al.: Oral Dis 2006; 12(5): 469–75. (clinical study)
- Weibrich G, et al.: Mund Kiefer Gesichtschir 2000; 4(3): 148–52. (preclinical study)
- Jung RE, et al.: Clin Oral Implants Res 2021; 32(12): 1455–65. (clinical study)
- PubMed search 08 August 2025; search term “bio-oss” (1,402 publications), https://pubmed.ncbi.nlm.nih.gov/?term=bio-oss
- Urban IA, et al.: Int J Periodontics Restorative Dent 2013; 33(3): 299–307. (clinical study)
- Cosyn J, et al.: J Clin Periodontol 2012; 39(10): 979–86. (clinical study)
- Camelo M, et al.: Int J Periodontics Restorative Dent 1998; 18(4): 321–31. (clinical study)
- Lundgren D, Slotte C: J Clin Periodontol 1999; 26(1): 56–62. (clinical study)
- Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2014; 34(5): 631–7. (clinical study)
Exceptional Results You Can Rely On
- Superior implant survival rate: Clinical evidence shows that using Geistlich Bio-Oss® as a bone graft material achieves implant survival rates above 97%, outperforming sites without grafting and those treated with other bone substitutes.12
- Unmatched volume stability: The slow resorption and high osteoconductivity of Geistlich Bio-Oss® support effective bone regeneration and long-term volume stability, forming a reliable base for excellent functional and esthetic outcomes.4-6,8,11
References:
- iData Research, China market report suite for dental bone graft substitutes and other biomaterials, iDATA_CHDBGS18_MS, Nov 2018. (market research)
- iData Research, Europe market report suite for dental bone graft substitutes and other biomaterials, iDATA_EUDBGS19_MS, Jul 2019. (market research)
- iData Research, US market report suite for dental bone graft substitutes and other biomaterials, iDATA_USDBGS19_MS, Jan 2019. (market research)
- Aghaloo TL, Moy PK: Int J Oral Maxillofac Implants 2007; 22 (Suppl): 49–70. (systematic review)
- Jung RE, et al.: Clin Oral Implants Res 2013; 24(10): 1065–73. (clinical study)
- Orsini G, et al.: J Biomed Mater Res B Appl Biomater 2005; 74(1): 448–57. (clinical study)
- Traini T, et al.: J Periodontol 2007; 78(5): 955–61. (clinical study)
- Mordenfeld A, et al.: Clin Oral Implants Res 2010; 21(9): 961–70. (clinical study)
- Maiorana C, et al.: Open Dent J 2011; 5: 71–78. (clinical study)
- Galindo-Moreno P, et al.: Clin Implant Dent Relat Res 2013; 15(6): 858–66. (clinical study)
- Chappuis V, et al.: J Dent Res 2018; 97(3): 266–74. (clinical study)
- Knoefler W, et al.: Int J Implant Dent 2016; 2(1): 25. (clinical study)
- Data on file. Geistlich Pharma AG, Wolhusen, Switzerland.
- Jiang D, et al.: J Periodontol 1999; 70(8): 834–9. (preclinical study)
- Beretta M, et al.: Int J Periodontics Restorative Dent 2025; 45(2): 209–19. (clinical study)
- GEM 21S® Instructions for Use
- Degidi M, et al.: Oral Dis 2006; 12(5): 469–75. (clinical study)
- Weibrich G, et al.: Mund Kiefer Gesichtschir 2000; 4(3): 148–52. (preclinical study)
- Jung RE, et al.: Clin Oral Implants Res 2021; 32(12): 1455–65. (clinical study)
- PubMed search 08 August 2025; search term “bio-oss” (1,402 publications), https://pubmed.ncbi.nlm.nih.gov/?term=bio-oss
- Urban IA, et al.: Int J Periodontics Restorative Dent 2013; 33(3): 299–307. (clinical study)
- Cosyn J, et al.: J Clin Periodontol 2012; 39(10): 979–86. (clinical study)
- Camelo M, et al.: Int J Periodontics Restorative Dent 1998; 18(4): 321–31. (clinical study)
- Lundgren D, Slotte C: J Clin Periodontol 1999; 26(1): 56–62. (clinical study)
- Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2014; 34(5): 631–7. (clinical study)
Perform With User Friendly and Time-Saving Products
- Fast liquid uptake: Thanks to its unique micro- and macro-porous structure, Geistlich Bio-Oss® rapidly absorbs blood, nutrients, and growth factors—faster than other bone substitutes. The granules are hydrated within seconds, and their pores fill with serum proteins, serving as a natural growth factor reservoir.13,14
- Enhanced healing performance: The combination of Geistlich Bio-Oss® with autologous bone or biologically derived products such as REGENFAST® or GEM 21S® promotes faster tissue regeneration.15,16 This effect is supported by the material’s osteoconductive properties, which make it an ideal scaffold for new bone formation.17,18
References:
- iData Research, China market report suite for dental bone graft substitutes and other biomaterials, iDATA_CHDBGS18_MS, Nov 2018. (market research)
- iData Research, Europe market report suite for dental bone graft substitutes and other biomaterials, iDATA_EUDBGS19_MS, Jul 2019. (market research)
- iData Research, US market report suite for dental bone graft substitutes and other biomaterials, iDATA_USDBGS19_MS, Jan 2019. (market research)
- Aghaloo TL, Moy PK: Int J Oral Maxillofac Implants 2007; 22 (Suppl): 49–70. (systematic review)
- Jung RE, et al.: Clin Oral Implants Res 2013; 24(10): 1065–73. (clinical study)
- Orsini G, et al.: J Biomed Mater Res B Appl Biomater 2005; 74(1): 448–57. (clinical study)
- Traini T, et al.: J Periodontol 2007; 78(5): 955–61. (clinical study)
- Mordenfeld A, et al.: Clin Oral Implants Res 2010; 21(9): 961–70. (clinical study)
- Maiorana C, et al.: Open Dent J 2011; 5: 71–78. (clinical study)
- Galindo-Moreno P, et al.: Clin Implant Dent Relat Res 2013; 15(6): 858–66. (clinical study)
- Chappuis V, et al.: J Dent Res 2018; 97(3): 266–74. (clinical study)
- Knoefler W, et al.: Int J Implant Dent 2016; 2(1): 25. (clinical study)
- Data on file. Geistlich Pharma AG, Wolhusen, Switzerland.
- Jiang D, et al.: J Periodontol 1999; 70(8): 834–9. (preclinical study)
- Beretta M, et al.: Int J Periodontics Restorative Dent 2025; 45(2): 209–19. (clinical study)
- GEM 21S® Instructions for Use
- Degidi M, et al.: Oral Dis 2006; 12(5): 469–75. (clinical study)
- Weibrich G, et al.: Mund Kiefer Gesichtschir 2000; 4(3): 148–52. (preclinical study)
- Jung RE, et al.: Clin Oral Implants Res 2021; 32(12): 1455–65. (clinical study)
- PubMed search 08 August 2025; search term “bio-oss” (1,402 publications), https://pubmed.ncbi.nlm.nih.gov/?term=bio-oss
- Urban IA, et al.: Int J Periodontics Restorative Dent 2013; 33(3): 299–307. (clinical study)
- Cosyn J, et al.: J Clin Periodontol 2012; 39(10): 979–86. (clinical study)
- Camelo M, et al.: Int J Periodontics Restorative Dent 1998; 18(4): 321–31. (clinical study)
- Lundgren D, Slotte C: J Clin Periodontol 1999; 26(1): 56–62. (clinical study)
- Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2014; 34(5): 631–7. (clinical study)
Why Your Patients Will Love the Results
- Clinically proven and trusted: Geistlich Bio-Oss® is the most widely used and clinically documented dental bone graft substitute, with more than 21 million patients treated, and over two decades of documented success.1-3,13,19,20
- Long-lasting esthetic results: Multiple studies confirm that Geistlich Bio-Oss® used with Geistlich Bio-Gide® leads to excellent long-term esthetic outcomes and stable peri‑implant health, even two decades after treatment.11,19
References:
- iData Research, China market report suite for dental bone graft substitutes and other biomaterials, iDATA_CHDBGS18_MS, Nov 2018. (market research)
- iData Research, Europe market report suite for dental bone graft substitutes and other biomaterials, iDATA_EUDBGS19_MS, Jul 2019. (market research)
- iData Research, US market report suite for dental bone graft substitutes and other biomaterials, iDATA_USDBGS19_MS, Jan 2019. (market research)
- Aghaloo TL, Moy PK: Int J Oral Maxillofac Implants 2007; 22 (Suppl): 49–70. (systematic review)
- Jung RE, et al.: Clin Oral Implants Res 2013; 24(10): 1065–73. (clinical study)
- Orsini G, et al.: J Biomed Mater Res B Appl Biomater 2005; 74(1): 448–57. (clinical study)
- Traini T, et al.: J Periodontol 2007; 78(5): 955–61. (clinical study)
- Mordenfeld A, et al.: Clin Oral Implants Res 2010; 21(9): 961–70. (clinical study)
- Maiorana C, et al.: Open Dent J 2011; 5: 71–78. (clinical study)
- Galindo-Moreno P, et al.: Clin Implant Dent Relat Res 2013; 15(6): 858–66. (clinical study)
- Chappuis V, et al.: J Dent Res 2018; 97(3): 266–74. (clinical study)
- Knoefler W, et al.: Int J Implant Dent 2016; 2(1): 25. (clinical study)
- Data on file. Geistlich Pharma AG, Wolhusen, Switzerland.
- Jiang D, et al.: J Periodontol 1999; 70(8): 834–9. (preclinical study)
- Beretta M, et al.: Int J Periodontics Restorative Dent 2025; 45(2): 209–19. (clinical study)
- GEM 21S® Instructions for Use
- Degidi M, et al.: Oral Dis 2006; 12(5): 469–75. (clinical study)
- Weibrich G, et al.: Mund Kiefer Gesichtschir 2000; 4(3): 148–52. (preclinical study)
- Jung RE, et al.: Clin Oral Implants Res 2021; 32(12): 1455–65. (clinical study)
- PubMed search 08 August 2025; search term “bio-oss” (1,402 publications), https://pubmed.ncbi.nlm.nih.gov/?term=bio-oss
- Urban IA, et al.: Int J Periodontics Restorative Dent 2013; 33(3): 299–307. (clinical study)
- Cosyn J, et al.: J Clin Periodontol 2012; 39(10): 979–86. (clinical study)
- Camelo M, et al.: Int J Periodontics Restorative Dent 1998; 18(4): 321–31. (clinical study)
- Lundgren D, Slotte C: J Clin Periodontol 1999; 26(1): 56–62. (clinical study)
- Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2014; 34(5): 631–7. (clinical study)
Leading Dental Bone Graft Substitute Trusted Worldwide
For over 40 years, Geistlich Bio‑Oss® has helped clinicians maintain bone volume and implant stability with confidence.4-6,8,11,12 Its slow resorption supports predictable, long-term results where it matters most.4-6,8,11,12
References:
- iData Research, China market report suite for dental bone graft substitutes and other biomaterials, iDATA_CHDBGS18_MS, Nov 2018. (market research)
- iData Research, Europe market report suite for dental bone graft substitutes and other biomaterials, iDATA_EUDBGS19_MS, Jul 2019. (market research)
- iData Research, US market report suite for dental bone graft substitutes and other biomaterials, iDATA_USDBGS19_MS, Jan 2019. (market research)
- Aghaloo TL, Moy PK: Int J Oral Maxillofac Implants 2007; 22 (Suppl): 49–70. (systematic review)
- Jung RE, et al.: Clin Oral Implants Res 2013; 24(10): 1065–73. (clinical study)
- Orsini G, et al.: J Biomed Mater Res B Appl Biomater 2005; 74(1): 448–57. (clinical study)
- Traini T, et al.: J Periodontol 2007; 78(5): 955–61. (clinical study)
- Mordenfeld A, et al.: Clin Oral Implants Res 2010; 21(9): 961–70. (clinical study)
- Maiorana C, et al.: Open Dent J 2011; 5: 71–78. (clinical study)
- Galindo-Moreno P, et al.: Clin Implant Dent Relat Res 2013; 15(6): 858–66. (clinical study)
- Chappuis V, et al.: J Dent Res 2018; 97(3): 266–74. (clinical study)
- Knoefler W, et al.: Int J Implant Dent 2016; 2(1): 25. (clinical study)
- Data on file. Geistlich Pharma AG, Wolhusen, Switzerland.
- Jiang D, et al.: J Periodontol 1999; 70(8): 834–9. (preclinical study)
- Beretta M, et al.: Int J Periodontics Restorative Dent 2025; 45(2): 209–19. (clinical study)
- GEM 21S® Instructions for Use
- Degidi M, et al.: Oral Dis 2006; 12(5): 469–75. (clinical study)
- Weibrich G, et al.: Mund Kiefer Gesichtschir 2000; 4(3): 148–52. (preclinical study)
- Jung RE, et al.: Clin Oral Implants Res 2021; 32(12): 1455–65. (clinical study)
- PubMed search 08 August 2025; search term “bio-oss” (1,402 publications), https://pubmed.ncbi.nlm.nih.gov/?term=bio-oss
- Urban IA, et al.: Int J Periodontics Restorative Dent 2013; 33(3): 299–307. (clinical study)
- Cosyn J, et al.: J Clin Periodontol 2012; 39(10): 979–86. (clinical study)
- Camelo M, et al.: Int J Periodontics Restorative Dent 1998; 18(4): 321–31. (clinical study)
- Lundgren D, Slotte C: J Clin Periodontol 1999; 26(1): 56–62. (clinical study)
- Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2014; 34(5): 631–7. (clinical study)
You Can’t Cut Corners When Leading Regenerative Dentistry
Our Swiss-made products—like Geistlich Bio-Oss® —meet the highest quality standards in sourcing, production, and logistics and have undergone rigorous testing in over 2,300 studies worldwide to ensure their safety and efficacy.
Geistlich offers a comprehensive suite of resources for dental professionals. It provides a variety of training and courses, available in multiple formats, covering a wide range of topics, from regeneration biology to effective patient communication. Geistlich also offers patient education materials to help dentists explain treatment options and support informed decision-making.
Leading Experts Trust Geistlich Bio-Oss®
“It is reassuring to use one of the best-documented, evidence-based biomaterials available, and be confident in long-term, predictable outcomes.”
Dr. Roberto Ledergerber Guayaquil, Ecuador
Long-term implant survival with Geistlich Bio-Oss®
A large retrospective study compared clinical outcomes in more than 3,000 patients and over 10,000 implants for up to 20 years. Geistlich Bio-Oss® achieved the highest implant survival rate among all evaluated treatment options.12
References
- iData Research, China market report suite for dental bone graft substitutes and other biomaterials, iDATA_CHDBGS18_MS, Nov 2018. (market research)
- iData Research, Europe market report suite for dental bone graft substitutes and other biomaterials, iDATA_EUDBGS19_MS, Jul 2019. (market research)
- iData Research, US market report suite for dental bone graft substitutes and other biomaterials, iDATA_USDBGS19_MS, Jan 2019. (market research)
- Aghaloo TL, Moy PK: Int J Oral Maxillofac Implants 2007; 22 (Suppl): 49–70. (systematic review)
- Jung RE, et al.: Clin Oral Implants Res 2013; 24(10): 1065–73. (clinical study)
- Orsini G, et al.: J Biomed Mater Res B Appl Biomater 2005; 74(1): 448–57. (clinical study)
- Traini T, et al.: J Periodontol 2007; 78(5): 955–61. (clinical study)
- Mordenfeld A, et al.: Clin Oral Implants Res 2010; 21(9): 961–70. (clinical study)
- Maiorana C, et al.: Open Dent J 2011; 5: 71–78. (clinical study)
- Galindo-Moreno P, et al.: Clin Implant Dent Relat Res 2013; 15(6): 858–66. (clinical study)
- Chappuis V, et al.: J Dent Res 2018; 97(3): 266–74. (clinical study)
- Knoefler W, et al.: Int J Implant Dent 2016; 2(1): 25. (clinical study)
- Data on file. Geistlich Pharma AG, Wolhusen, Switzerland.
- Jiang D, et al.: J Periodontol 1999; 70(8): 834–9. (preclinical study)
- Beretta M, et al.: Int J Periodontics Restorative Dent 2025; 45(2): 209–19. (clinical study)
- GEM 21S® Instructions for Use
- Degidi M, et al.: Oral Dis 2006; 12(5): 469–75. (clinical study)
- Weibrich G, et al.: Mund Kiefer Gesichtschir 2000; 4(3): 148–52. (preclinical study)
- Jung RE, et al.: Clin Oral Implants Res 2021; 32(12): 1455–65. (clinical study)
- PubMed search 08 August 2025; search term “bio-oss” (1,402 publications), https://pubmed.ncbi.nlm.nih.gov/?term=bio-oss
- Urban IA, et al.: Int J Periodontics Restorative Dent 2013; 33(3): 299–307. (clinical study)
- Cosyn J, et al.: J Clin Periodontol 2012; 39(10): 979–86. (clinical study)
- Camelo M, et al.: Int J Periodontics Restorative Dent 1998; 18(4): 321–31. (clinical study)
- Lundgren D, Slotte C: J Clin Periodontol 1999; 26(1): 56–62. (clinical study)
- Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2014; 34(5): 631–7. (clinical study)
01/05
Versatile bone graft substitute for GBR, 2-stage implant placement, periodontal and peri-implant defect treatment
Geistlich Bio‑Oss® is a versatile dental bone grafting material suitable for Guided Bone Regeneration (GBR)11, 2‑stage implant placement21, and the treatment of periodontal22-24 and peri‑implant25 defects. Its adaptability and proven clinical performance make it a dependable choice across indications.11,21-25
References
- iData Research, China market report suite for dental bone graft substitutes and other biomaterials, iDATA_CHDBGS18_MS, Nov 2018. (market research)
- iData Research, Europe market report suite for dental bone graft substitutes and other biomaterials, iDATA_EUDBGS19_MS, Jul 2019. (market research)
- iData Research, US market report suite for dental bone graft substitutes and other biomaterials, iDATA_USDBGS19_MS, Jan 2019. (market research)
- Aghaloo TL, Moy PK: Int J Oral Maxillofac Implants 2007; 22 (Suppl): 49–70. (systematic review)
- Jung RE, et al.: Clin Oral Implants Res 2013; 24(10): 1065–73. (clinical study)
- Orsini G, et al.: J Biomed Mater Res B Appl Biomater 2005; 74(1): 448–57. (clinical study)
- Traini T, et al.: J Periodontol 2007; 78(5): 955–61. (clinical study)
- Mordenfeld A, et al.: Clin Oral Implants Res 2010; 21(9): 961–70. (clinical study)
- Maiorana C, et al.: Open Dent J 2011; 5: 71–78. (clinical study)
- Galindo-Moreno P, et al.: Clin Implant Dent Relat Res 2013; 15(6): 858–66. (clinical study)
- Chappuis V, et al.: J Dent Res 2018; 97(3): 266–74. (clinical study)
- Knoefler W, et al.: Int J Implant Dent 2016; 2(1): 25. (clinical study)
- Data on file. Geistlich Pharma AG, Wolhusen, Switzerland.
- Jiang D, et al.: J Periodontol 1999; 70(8): 834–9. (preclinical study)
- Beretta M, et al.: Int J Periodontics Restorative Dent 2025; 45(2): 209–19. (clinical study)
- GEM 21S® Instructions for Use
- Degidi M, et al.: Oral Dis 2006; 12(5): 469–75. (clinical study)
- Weibrich G, et al.: Mund Kiefer Gesichtschir 2000; 4(3): 148–52. (preclinical study)
- Jung RE, et al.: Clin Oral Implants Res 2021; 32(12): 1455–65. (clinical study)
- PubMed search 08 August 2025; search term “bio-oss” (1,402 publications), https://pubmed.ncbi.nlm.nih.gov/?term=bio-oss
- Urban IA, et al.: Int J Periodontics Restorative Dent 2013; 33(3): 299–307. (clinical study)
- Cosyn J, et al.: J Clin Periodontol 2012; 39(10): 979–86. (clinical study)
- Camelo M, et al.: Int J Periodontics Restorative Dent 1998; 18(4): 321–31. (clinical study)
- Lundgren D, Slotte C: J Clin Periodontol 1999; 26(1): 56–62. (clinical study)
- Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2014; 34(5): 631–7. (clinical study)
Geistlich Bio-Oss®: Sizes and Granule Options
Geistlich Bio-Oss® is available in seven quantities with small or large granules to meet your clinical needs:
Small granules (0.25 – 1 mm): Adapt well to surface contours; especially suitable for smaller defects and for contouring around autogenous blocks. Available volumes: 0.25 g ≈ 0.5 cc; 0.5 g ≈ 1 cc; 1 g ≈ 2 cc; 2 g ≈ 4 cc.
Large granules (1 – 2 mm): Recommended for larger augmentations. Available volumes: 0.5 g ≈ 1.5 cc; 1 g ≈ 3 cc; 2 g ≈ 6 cc.
*Product availability may vary by country.
