Lipogems®
Autologous Micro-fragmented Adipose Tissue
The Lipogems® system is a sterile single-use class II A disposable medical device intended for the closed-loop processing and transferring of autologous adipose tissue in a single surgical step. The harvested tissue is minimally manipulated and used to repair, restore or replace damaged tissue and can be used in AMIC®+ procedure to combine the proven procedure with biological adjuvants.
A technical note describing the technique was published in 2025 by Debieux et al.1
In a case series of 18 patients with a 5-years follow-up, patients showed progressive significant improvement of all scores starting early at six months, and further increased values were noted till the last follow-up at 60 months. Mean subjective pre-operative IKDC score of 36.1 significantly increased to 86.4 at 24 months and to 87.2 at 60 months. Mean pre-operative Lysholm score of 44.4 reached 93.5 at two years and 93.5 at five years. MRI examination showed early subchondral lamina regrowth and progressive maturation of repair tissue and filling of defects. The mean total MOCART score showed that a significant improvement from two year follow-up (69.1 points) to last follow-up was 81.9 points (range, 30–100 points, SD 24). Complete filling of the defect at the level of the surrounding cartilage was found in 77.8%.2
The Lipogems® advantages:
- No oxidation or mechanical damage to the cell population
- Fluidity and viscosity of the obtained product allows an injection using very fine needles
- Single use complete kit
- No centrifugation needed
References:
- Debieux, P. et al. LIPO-AMIC Technique Description: Autologous Matrix Induced–Chondrogenesis With Microfragmented Adipose Tissue Graft. Arthrosc. Tech. 103279 (2024) doi:10.1016/j.eats.2024.103279.
- Sciarretta F.V. et al. One-stage cartilage repair using the autologous matrix-induced chondrogenesis combined with simultaneous use of autologous adipose tissue graft and adipose tissue mesenchymal cells technique: clinical results and magnetic resonance imaging evaluation at five-year follow-up. Int Orthop. 2024 Jan;48(1):267-277. doi: 10.1007/s00264-023-05921-8. Epub 2023 Sep 1. PMID: 37656198; PMCID: PMC10766726.
Lipogems® is distributed by Geistlich in Germany and Brazil.
Legal Manufacturer:
Lipogems
Viale Bianca Maria 24
20129 Milano
Italy
Website: Lipogems.com